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LIF Antibody, Rabbit PAb

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Description: Active  
Expression host: Human Cells  
  • Slide 1
14890-H08H-5
14890-H08H-20
14890-H08H-100
5 µg 
20 µg 
100 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
14890-H02H-5
14890-H02H-20
14890-H02H-100
5 µg 
20 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
14890-HNAH-50
14890-HNAH-20
50 µg 
20 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
50755-M08H-5
50755-M08H-20
50755-M08H-100
5 µg 
20 µg 
100 µg 
Add to Cart
Description:   
Expression host: Human Cells  
  • Slide 1
50756-MNAH-5
50756-MNAH-20
50756-MNAH-100
5 µg 
20 µg 
100 µg 
Add to Cart

MP200730 

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Leukemia Inhibitory Factor/LIF antibody Background

Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It’s involved in growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. LIF has potent proinflammatory property, being the inducer of the acute phase protein synthesis and affecting the cell recruitment into the area of damage or inflammation. LIF is also one of the cytokines that are capable to regulate the differentiation of embryonic stem cells, hematopoietic and neuronal cells. LIF binds to the specific LIF receptor (LIFR-α) which forms a heterodimer with a specific subunit common to all members of that family of receptors, the GP130 signal transducing subunit. This leads to activation of the JAK/STAT and MAPK cascades. Due to its polyfunctional activities, LIF is involved in the pathogenic events and development of many diseases of various origin.

Mouse Leukemia Inhibitory Factor/LIF antibody References
  • Salas EM, et al. (2011) LIF, a Novel STAT5-Regulated Gene, Is Aberrantly Expressed in Myeloproliferative Neoplasms. Genes Cancer. 2 (5): 593-6.
  • Chodorowska G, et al. (2004) Leukemia inhibitory factor (LIF) and its biological activity. Ann Univ Mariae Curie Sklodowska Med. 59 (2): 189-93.
  • Garcia-Campana AM, et al. (2007) LIF detection of peptides and proteins in CE. Electrophoresis. 28 (1-2): 208-32.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"