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FSTL1 Antibody, Rabbit PAb

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Expression host: Human Cells  
  • Slide 1
80885-H08H-50
80885-H08H-200
50 µg 
200 µg 
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Expression host: Human Cells  
  • Slide 1
10924-H08H-50
10924-H08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
51127-M08H-50
51127-M08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
51127-M02H-50
51127-M02H-100
50 µg 
100 µg 
Add to Cart

FSTL1 AntibodyRelated Products

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FSTL1 antibody Background

Follistatin-related protein 1 (FSTL1)  is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling.

Mouse FSTL1 antibody References
  • Rosenberg MI, et al. (2006) MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206. J Cell Biol. 175(1): 77-85.
  • Ouchi N, et al. (2010) DIP2A functions as a FSTL1 receptor. J Biol Chem. 285(10): 7127-34.
  • Geng Y, et al. (2011) Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci U S A. 108(17): 7058-63.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"