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Mouse Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid, C-His tag

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Expression host: Baculovirus-Insect Cells  
  • Slide 1
10276-H08B-20
10276-H08B-10
20 µg 
10 µg 
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Description: Active  
Expression host: Baculovirus-Insect Cells  
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50268-M08B-50
50268-M08B-20
50 µg 
20 µg 
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Reactivity: Human  
Application: ELISA  
    10276-R457-50
    10276-R457-100
    50 µg 
    100 µg 
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    Reactivity: Human  
    Application: ELISA  
      10276-R455-50
      10276-R455-100
      50 µg 
      100 µg 
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      Reactivity: Human  
      Application: ELISA  WB  IF  IP  ICC/IF  
      • Slide 1
      • Slide 1
      • Slide 1
      10276-R201-50
      10276-R201-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  WB  IP  
      • Slide 1
      • Slide 1
      10276-RP02-50
      10276-RP02-200
      10276-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  WB  IP  
      • Slide 1
      • Slide 1
      50268-RP02-50
      50268-RP02-200
      50268-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  
        50268-RP01-400
        50268-RP01-200
        50268-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart

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        Leukotriene A4 Hydrolase/LTA4H cdna-clone Background

        Leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H and LTA4, is cytoplasm protein which belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity. The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs, arachidonic acid was converted into the unstable intermediate epoxide LTA4, which may in turn be conjugated with glutathione to form the spasmogenic LTC4, or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium, and also modulates immune responses. As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is regarded as a therapeutic target for inflammation.

        Mouse Leukotriene A4 Hydrolase/LTA4H cdna-clone References
      • Mancini, JA. et al.,1995, Eur. J. Biochem. 231: 65-71.
      • Orning, L. et al., 1994, J. Biol. Chem. 269: 11269-73.
      • Rudberg, PC. et al., 2004, J. Biol. Chem. 279: 27376-82.
      • Qiu, H. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 8161-6.
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