Text Size:AAA

Mouse KLK-6 ORF mammalian expression plasmid, C-His tag

DatasheetReviewsProtocols
Expression host: Human Cells  
  • Slide 1
  • Slide 1
12142-HCCH-20
12142-HCCH-10
20 µg 
10 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
12142-H08H-10
12142-H08H-20
10 µg 
20 µg 
Add to Cart
Reactivity: Mouse  
Application: ELISA  
    50255-RP01-200
    50255-RP01-100
    50255-RP01-400
    200 µg 
    100 µg 
     
    Add to Cart
    Reactivity: Mouse  
    Application: ELISA  WB  
    • Slide 1
    50255-T48-100
    50255-T48-50
    100 µg 
    50 µg 
    Add to Cart

    Browse KLK6/Kallikrein 6/Neurosin CRO Products by

    KLK6/Kallikrein 6/Neurosin Gene ProductsRelated Products

    Related Products

    Featured Reagent Products

    KLK6/Kallikrein 6/Neurosin cdna-clone Background

    KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. KLK6 degrades alpha-synuclein and prevents its polymerization, indicating that KLK6 may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. Klk7 may be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

    Mouse KLK6/Kallikrein 6/Neurosin cdna-clone References
  • Krenzer S, et al. (2011) Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment. J Invest Dermatol. 131(11):2281-8.
  • Nathalie HV, et al. (2009) High kallikrein-related peptidase 6 in non-small cell lung cancer cells: an indicator of tumour proliferation and poor prognosis. J Cell Mol Med. 13(9B):4014-22.
  • Kim JT, et al. (2011) Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer. Cancer. 117(12):2608-19.
  • Scarisbrick IA, et al. (2011) Functional role of kallikrein 6 in regulating immune cell survival. PLoS One. 6(3):e18376.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"