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Human CD171 / N-CAML1 / L1CAM Protein (His Tag)

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Reactivity: Human  
Application: ELISA  
    10140-RP01-400
    10140-RP01-200
    10140-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    • Slide 1
    10140-MM03-P-25
    10140-MM03-P-100
    25 Test 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10140-MM03-A-25
    10140-MM03-A-100
    25 Test 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10140-MM01-50
      10140-MM01-200
      10140-MM01-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      10140-MM03-50
      10140-MM03-200
      10140-MM03-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10140-R004-50
        10140-R004-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: IHC-P  FCM  IF  ICC/IF  
        • Slide 1
        • Slide 1
        • Slide 1
        10140-R014-50
        10140-R014-100
        10140-R014-1
        50 µg 
        100 µg 
        1 mg 
        Add to Cart
        Reactivity: Human  
        Application: 
          10140-R001-50
          10140-R001-100
          10140-R001-1
          50 µg 
          100 µg 
          1 mg 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10140-R014-P-25
          10140-R014-P-100
          25 Test 
          100 Tests 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            10140-RP02-50
            10140-RP02-200
            10140-RP02-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Human  
            Application: FCM  
            • Slide 1
            10140-R014-F-25
            10140-R014-F-100
            25 Test 
            100 Tests 
            Add to Cart
            Reactivity: Mouse  
            Application: 
            • Slide 1
            101901-T08-50
            101901-T08-200
            101901-T08-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart

            CD171/L1CAM ELISA Pair Set

            Detection Limit:
            SEK10140-5
            SEK10140-15
            5 Plates 
            15 Plates 
            Add to Cart

            CD171/L1CAM Recombinant ProteinRelated Products

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            CD171/L1CAM protein Background

            L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and in a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan and intergrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait and adducted thumbs) and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy.

            Human CD171/L1CAM protein References
          • Meier F, et al. (2006) The adhesion molecule L1 (CD171) promotes melanoma progression. Int J Cancer. 119(3): 549-55.
          • Gavert N, et al. (2008) L1-CAM in cancerous tissues. Expert Opin Biol Ther. 8(11): 1749-57.
          • Issa Y, et al. (2009) Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration. J Mol Med. 87(1): 99-112.
          • Weidle UH, et al. (2009) L1-CAM as a target for treatment of cancer with monoclonal antibodies. Anticancer Res. 29(12): 4919-31.
          • Raveh S, et al. (2009) L1 cell adhesion molecule (L1CAM) in invasive tumors. Cancer Lett. 282(2): 137-45.
          • Wolterink S, et al. (2010) Therapeutic antibodies to human L1CAM: functional characterization and application in a mouse model for ovarian carcinoma. Cancer Res. 70(6): 2504-15.
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