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Mouse IGFBP4 Gene ORF cDNA clone expression plasmid, C-His tag

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Description: Active  
Expression host: Human Cells  
  • Slide 1
10967-H08H-5
10967-H08H-20
10967-H08H-100
5 µg 
20 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
50250-M08H-5
50250-M08H-20
50250-M08H-100
5 µg 
20 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
90080-C08H-5
90080-C08H-20
90080-C08H-100
5 µg 
20 µg 
100 µg 
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Reactivity: Human  
Application: ELISA  
    10967-MM02-50
    10967-MM02-200
    10967-MM02-100
    50 µg 
    200 µg 
    100 µg 
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    Reactivity: Mouse  
    Application: ELISA  
      50250-RP02-50
      50250-RP02-200
      50250-RP02-100
      50 µg 
      200 µg 
      100 µg 
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      Reactivity: Cynomolgus  
      Application: ELISA  
        90080-MM01-50
        90080-MM01-200
        90080-MM01-100
        50 µg 
        200 µg 
        100 µg 
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        Reactivity: Cynomolgus  
        Application: ELISA  IHC-P  
        • Slide 1
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        90080-T24-50
        90080-T24-200
        90080-T24-100
        50 µg 
        200 µg 
        100 µg 
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        IGFBP4 cdna-clone Background

        Insulin-like growth factor binding protein 4 (IGFBP-4) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are clearly distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF, or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. Expression of IGFBP-4 mRNA in nontransgenic littermates was maximal in liver and kidney. IGFBP-4 is a functional antagonist of IGF-I action on SMC. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity.

        Mouse IGFBP4 cdna-clone References
      • Wang J, et al. (1998) Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Endocrinology. 139(5): 2605-14.
      • Chernausek SD, et al. (1995) Proteolytic cleavage of insulin-like growth factor binding protein 4 (IGFBP-4). Localization of cleavage site to non-homologous region of native IGFBP-4. J Biol Chem. 1995 May 12;270(19):11377-82.
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