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Human MEP1A / PPHA Protein (His Tag)

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Reactivity: Human  
Application: ELISA  
    10133-RP01-400
    10133-RP01-200
    10133-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10133-R009-50
      10133-R009-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10133-R017-50
        10133-R017-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  IHC-P  
        • Slide 1
        • Slide 1
        50057-R001-50
        50057-R001-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  WB  
        • Slide 1
        50057-RP01-400
        50057-RP01-200
        50057-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  WB  
        • Slide 1
        50057-RP02-50
        50057-RP02-200
        50057-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart

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        MEP1A protein Background

        Meprin A subunit alpha, also known as MEP1A, and Endopeptidase-2, is a single-pass type I  membrane protein which belongs to the peptidase M12A family. MEP1A contains one EGF-like domain, one MAM domain, and one MATH domain. Meprins are unique plasma membrane and secreted metalloproteinases that are highly regulated at the transcriptional and post-translational levels. Meprin alpha and beta subunits are abundantly expressed in kidney and intestinal epithelial cells, are secreted into the urinary tract and intestinal lumen, and are found in leukocytes and cancer cells under certain conditions. Meprins are capable of proteolytically degrading extracellular matrix proteins, proteolytically processing bioactive proteins, and play a role in inflammatory processes. Meprin A and B are highly regulated, secreted and cell-surface homo- and hetero-oligomeric enzymes. Meprins are abundantly expressed in kidney and intestine. The multidomain alpha and beta subunits have high sequence identity. They have very different substrate specificities, oligomerization potentials and are differentially regulated. Meprin A appears to be an important therapeutic target and urinary excretion appears to be a potential biomarker of acute kidney injury ( AKI ).

        Human MEP1A protein References
      • Bertenshaw,GP. et al., 2002, Biol Chem. 383 (7-8):1175-83.
      • Bond, JS. et al., 2005, FEBS Lett. 579 (15): 3317-22.
      • Herzog, C. et al., 2007, Kidney Int. 71 (10): 1009-18.
      • Yura, RE. et al., 2009, Am J Physiol Renal Physiol. 296 (1): F135-44.
      • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"