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IL1R2 / IL1RB / CD121b Antibody, Rabbit MAb

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Description: Active  
Expression host: Human Cells  
  • Slide 1
10111-H02H-50
10111-H02H-100
50 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
10111-H08H-50
10111-H08H-100
50 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
10111-HCCH-50
10111-HCCH-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
51090-M08H-200
51090-M08H-100
200 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
51090-M02H-50
51090-M02H-100
50 µg 
100 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
80196-R08H-50
80196-R08H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
90120-C02H-50
90120-C02H-100
50 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
70093-D02H-50
70093-D02H-20
50 µg 
20 µg 
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IL-1R2/CD121b ELISA Pair Set

Detection Limit:
SEK80196-5
SEK80196-15
5 Plates 
15 Plates 
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Detection Limit: 9.375 pg/ml
SEK10111-5
SEK10111-15
5 Plates 
15 Plates 
Add to Cart

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IL-1R2/CD121b antibody Background

Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.

Human IL-1R2/CD121b antibody References
  • Cannon JG, et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.
  • Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.
  • Van der Poll T, et al. (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.
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