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Human IL1R2 / IL1RB / CD121b Protein (His Tag)

DatasheetReviewsProtocols
Reactivity: Human  
Application: ELISA  
    10111-RP02-50
    10111-RP02-200
    10111-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10111-MM11-50
      10111-MM11-200
      10111-MM11-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10111-RP01-400
        10111-RP01-200
        10111-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10111-R020-50
          10111-R020-100
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  
            10111-MM04-50
            10111-MM04-200
            10111-MM04-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Human  
            Application: 
              10111-MM02-50
              10111-MM02-200
              10111-MM02-100
              10111-MM02-1
              50 µg 
              200 µg 
              100 µg 
              1 mg 
              Add to Cart
              Reactivity: Human  
              Application: 
                10111-R041-50
                10111-R041-100
                10111-R041-1
                50 µg 
                100 µg 
                1 mg 
                Add to Cart
                Reactivity: Mouse  
                Application: ELISA  
                  51090-RP01-400
                  51090-RP01-200
                  51090-RP01-100
                  400 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  Reactivity: Mouse  
                  Application: ELISA  
                    51090-T16-50
                    51090-T16-200
                    51090-T16-100
                    50 µg 
                    200 µg 
                    100 µg 
                    Add to Cart
                    Reactivity: Rat  
                    Application: 
                      80196-R161-50
                      80196-R161-100
                      80196-R161-1
                      50 µg 
                      100 µg 
                      1 mg 
                      Add to Cart
                      Reactivity: Rat  
                      Application: ELISA  
                        80196-MM05-50
                        80196-MM05-200
                        80196-MM05-100
                        80196-MM05-1
                        50 µg 
                        200 µg 
                        100 µg 
                        1 mg 
                        Add to Cart
                        Reactivity: Rat  
                        Application: ELISA  
                          80196-RP01-400
                          80196-RP01-200
                          80196-RP01-100
                          400 µg 
                          200 µg 
                          100 µg 
                          Add to Cart
                          Reactivity: Rat  
                          Application: ELISA  
                            80196-R021-50
                            80196-R021-100
                            50 µg 
                            100 µg 
                            Add to Cart

                            IL-1R2/CD121b ELISA Pair Set

                            Detection Limit:
                            SEK80196-5
                            SEK80196-15
                            5 Plates 
                            15 Plates 
                            Add to Cart
                            Detection Limit: 9.375 pg/ml
                            SEK10111-5
                            SEK10111-15
                            5 Plates 
                            15 Plates 
                            Add to Cart

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                            IL-1R2/CD121b protein Background

                            Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.

                            Human IL-1R2/CD121b protein References
                          • Cannon JG, et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.
                          • Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.
                          • Van der Poll T, et al. (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.
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