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Human Cadherin-8 / CDH8 Gene ORF cDNA clone expression plasmid, C-Flag tag

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Expression host: Human Cells  
  • Slide 1
10144-H08H-5
10144-H08H-20
10144-H08H-10
5 µg 
20 µg 
10 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
80278-R08H-5
80278-R08H-10
5 µg 
10 µg 
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Expression host: Human Cells  
  • Slide 1
80278-RCCH-5
80278-RCCH-20
80278-RCCH-10
5 µg 
20 µg 
10 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10144-RP01-400
    10144-RP01-200
    10144-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10144-R032-50
      10144-R032-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10144-T16-50
        10144-T16-200
        10144-T16-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart

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        Cadherin-8 / CDH8 cdna-clone Background

        Cadherins are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Type I cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of five subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I  cadherins. Cadherin 8, also known as CDH 8, is a type I I classical cadherin belonging to the cadherin superfamily. As mainly expressed in brain, CDH8 is found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts, and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Human Cadherin 8 is a 799 amino acid single-pass type I  transmembrane protein with a putative 29 aa signal sequence, and a 32 aa propeptide, a 560 aa mature extracellular domain, a 21 aa transmembrane domain and a 157 aa cytoplasmic domain. The human, mouse and rat proteins share approximately 98% homology.

        Human Cadherin-8 / CDH8 cdna-clone References
      • Tanihara, H. et al., 1994, Cell Adhes. Comm. 2:15-26.
      • Kido, M. et al., 1998, Genomics 48:186-194.
      • Yamagata, K. et al., 1999, J. Biol. Chem. 274:19473-19479.
      • Nollet, F. et al., 2000, J. Mol. Biol. 299:551-572.
      • Blaschke, S. et al., 2002, Int. J. Cancer. 101 (4): 327-334.
      • Strausberg,R.L. et al., 2003, Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903.
      • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"