Quick Order

Mouse IL12A / IL-12A transcript variant 1 Gene ORF cDNA clone in cloning vector

DatasheetReviewsProtocols
Expression host: Human Cells  
  • Slide 1
10021-H02H-50
10021-H02H-20
50 µg 
20 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
10021-H08H-500
10021-H08H-5
10021-H08H-20
10021-H08H-100
10021-H08H-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
90290-C02H-50
90290-C02H-20
50 µg 
20 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10021-MM05-50
    10021-MM05-200
    10021-MM05-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10021-RP01-400
      10021-RP01-200
      10021-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10021-R006-50
        10021-R006-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  WB  IHC-P  
        • Slide 1
        10021-RP02-50
        10021-RP02-200
        10021-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: WB  
        • Slide 1
        100321-T32-50
        100321-T32-200
        100321-T32-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart

        IL12A / IL-12A cDNA ORF CloneRelated Products

        Related Products

        Featured Reagent Products

        IL12A / IL-12A cdna-clone Background

        Interleukin-12 subunit alpha (IL12A/IL-12p35) is also known as Cytotoxic lymphocyte maturation factor 35 kDa subunit, cytotoxic lymphocyte maturation factor 1, p35, NK cell stimulatory factor chain 1, and interleukin-12 alpha chain. IL12A/IL-12p35 is a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. IL12A/IL-12p35 is required for the T-cell-independent induction of IFN-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. In clinical, IL-12 remains a very promising immunotherapeutic agent because recent cancer vaccination studies in animal models and humans have demonstrated its powerful adjuvant properties. The immune modulating characteristics of IL-12 considered responsible for the adjuvant effects, as well as the results of animal and human cancer vaccination studies with IL-12 applied as an adjuvant. IL12A/IL-12p35 indicates a cytokine which is important in the development of prostate cancer.

        Mouse IL12A / IL-12A cdna-clone References
      • Sattler HP, et al. (2000) Novel amplification unit at chromosome 3q25-q27 in human prostate cancer. Prostate. 45(3): 207-15.
      • Lamont AG, et al. (1996) IL-12: a key cytokine in immune regulation. Immunol Today. 17(5): 214-7.
      • Portielje JE, et al. (2003) IL-12: a promising adjuvant for cancer vaccination. Cancer Immunol Immunother. 52(3): 133-44.
      • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"