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Human ACE2 / Angiotensin-Converting Enzyme 2 HEK293 Cell Lysate (WB positive control)

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Description: Active  
Expression host: Human Cells  
  • Slide 1
10108-H02H-20
10108-H02H-10
20 µg 
10 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
10108-H05H-50
10108-H05H-10
50 µg 
10 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
50249-M03H-20
50249-M03H-10
20 µg 
10 µg 
Add to Cart
Expression host: Human Cells  
  • Slide 1
50249-M08H-20
50249-M08H-10
20 µg 
10 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
80031-R08H-20
80031-R08H-10
20 µg 
10 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
90211-C08H-20
90211-C08H-10
20 µg 
10 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
90211-C02H-20
90211-C02H-10
20 µg 
10 µg 
Add to Cart
Reactivity: Human  
Application: 
    10108-RP01-400
    10108-RP01-200
    10108-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  WB  IHC-P  
    • Slide 1
    • Slide 1
    • Slide 1
    10108-T56-50
    10108-T56-200
    10108-T56-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Rat  
    Application: IHC-P  
    • Slide 1
    • Slide 1
    80031-R039-50
    80031-R039-100
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Rat  
    Application: 
      80031-R003-50
      80031-R003-100
      80031-R003-1
      50 µg 
      100 µg 
      1 mg 
      Add to Cart
      Reactivity: Rat  
      Application: 
        80031-MM04-50
        80031-MM04-200
        80031-MM04-100
        80031-MM04-1
        50 µg 
        200 µg 
        100 µg 
        1 mg 
        Add to Cart
        Reactivity: Rat  
        Application: ELISA  
          80031-RP02-50
          80031-RP02-200
          80031-RP02-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Rat  
          Application: ELISA  
            80031-RP01-400
            80031-RP01-200
            80031-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Rat  
            Application: ELISA  
              80031-R001-50
              80031-R001-100
              50 µg 
              100 µg 
              Add to Cart

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              ACE2 / Angiotensin-Converting Enzyme 2 lysate_category Background

              Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme, an homolog of ACE, hydrolyzes angiotensin (Ang) I to produce Ang-(1-9), which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus, the major biologically active product of ACE2 is Ang-(1-7), which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis.

              Human ACE2 / Angiotensin-Converting Enzyme 2 lysate_category References
            • Koitka A, et al. (2008) Angiotensin converting enzyme 2 in the kidney. Clin Exp Pharmacol Physiol. 35(4): 420-5.
            • Raizada MK, et al. (2007) ACE2: a new target for cardiovascular disease therapeutics. J Cardiovasc Pharmacol. 50(2): 112-9.
            • Imai Y, et al. (2007) Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 74(3): 405-10.
            • Turner AJ, et al. (2004) ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci. 25(6): 291-4.
            • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"