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Carbonic Anhydrase IX / CA9 Antibody, Rabbit PAb

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Description: Active  
Expression host: Human Cells  
  • Slide 1
10107-H02H-20
10107-H02H-10
20 µg 
10 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
10107-H08H-20
10107-H08H-100
10107-H08H-10
20 µg 
100 µg 
10 µg 
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Description: Active  
Expression host: Human Cells  
  • Slide 1
50660-M08H-20
50660-M08H-10
20 µg 
10 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
70028-D08H-20
70028-D08H-10
20 µg 
10 µg 
Add to Cart
Description: Active  
Expression host: Human Cells  
  • Slide 1
70028-D02H-20
70028-D02H-10
20 µg 
10 µg 
Add to Cart

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Carbonic Anhydrase IX/CA9 antibody Background

Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Human Carbonic Anhydrase IX/CA9 antibody References
  • Loncaster JA, et al. (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 61(17): 6394-9.
  • Zvada J, et al. (2003) Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Br J Cancer. 89(6): 1067-71.
  • Pan P, et al. (2006) Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. J Physiol. 571(Pt 2): 319-27.
  • Zhou GX, et al. (2010) Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials. Urology. 75(2): 257-61.
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