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Human Carbonic Anhydrase IX / CA9 Protein (His Tag)

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Reactivity: Human  
Application: ELISA  WB  IP  
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10107-R003-50
10107-R003-100
50 µg 
100 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  IHC-P  
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10107-RP02-50
10107-RP02-200
10107-RP02-100
50 µg 
200 µg 
100 µg 
Add to Cart
Reactivity: Human  
Application: 
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10107-T48-50
10107-T48-200
10107-T48-100
50 µg 
200 µg 
100 µg 
Add to Cart
Reactivity: Human  
Application: ELISA  
    10107-RP01-400
    10107-RP01-200
    10107-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  IHC-P  
    • Slide 1
    • Slide 1
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    10107-R005-50
    10107-R005-100
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  FCM  
    • Slide 1
    10107-R036-50
    10107-R036-100
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Mouse  
    Application: ELISA  
      50660-RP01-400
      50660-RP01-200
      50660-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  WB  IHC-P  
      • Slide 1
      • Slide 1
      • Slide 1
      50660-RP02-50
      50660-RP02-200
      50660-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: IHC-P  
      • Slide 1
      50660-R001-50
      50660-R001-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Canine  
      Application: ELISA  WB  IP  
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      70028-T52-50
      70028-T52-200
      70028-T52-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Canine  
      Application: ELISA  
        70028-RP01-400
        70028-RP01-200
        70028-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart

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        Carbonic Anhydrase IX/CA9 protein Background

        Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.

        Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

        Human Carbonic Anhydrase IX/CA9 protein References
      • Loncaster JA, et al. (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 61(17): 6394-9.
      • Zvada J, et al. (2003) Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Br J Cancer. 89(6): 1067-71.
      • Pan P, et al. (2006) Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. J Physiol. 571(Pt 2): 319-27.
      • Zhou GX, et al. (2010) Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials. Urology. 75(2): 257-61.
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