Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
- Pitti R M. et al., 1998, Nature. 396 (6712): 699-703.
- Hane M. et al., 1995, FEBS Lett. 373 (3): 265-8.
- Schneider P. et al., 1997, J Biol Chem. 272 (30): 18827-33.