TRH cDNA ORF Clone in Cloning Vector, Human

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TRH cDNA ORF Clone in Cloning Vector, Human: General Information

Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
729 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human thyrotropin-releasing hormone.
Plasmid
Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

TRH cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

TRH cDNA ORF Clone in Cloning Vector, Human: Synonyms

Pro-TRH cDNA ORF Clone, Human; TRF cDNA ORF Clone, Human

TRH Background Information

Thyrotropin-releasing hormone (TRH) is the first hypothalamic hypophysiotropic neuropeptide whose sequence has been chemically characterized. The primary structure of TRH (pGlu-His-Pro-NH(2)) has been fully conserved across the vertebrate phylum. TRH is generated from a large precursor protein that contains multiple repeats of the TRH progenitor tetrapeptide Gln-His-Pro-Gly. In all tetrapods, TRH-expressing neurons located in the hypothalamus project towards the external zone of the median eminence. TRH has an important role in the regulation of energy homeostasis, feeding behavior, thermogenesis, and autonomic regulation. TRH causes a variety of thyroidal and non-thyroidal effects, the best known being the feedback regulation of thyroid hormone levels. TRH controls energy homeostasis mainly through its Hypophysiotropic Actions to regulate circulating thyroid hormone levels.
Full Name
thyrotropin releasing hormone
References
  • Singh O, et al. (2019) Thyrotropin-releasing hormone (trh) in the brain and pituitary of the teleost, clarias batrachus and its role in regulation of hypophysiotropic dopamine neurons. J Comp Neurol 527 (6): 1070-1101.
  • Shibusawa N, et al. (2008) Thyrotropin-releasing hormone (trh) in the cerebellum. Cerebellum 7 (1): 84-95.
  • Galas L, et al. (2009) Trh acts as a multifunctional hypophysiotropic factor in vertebrates. Gen Comp Endocrinol 164 (1): 40-50.
  • Fröhlich E, et al. (2019) The forgotten effects of thyrotropin-releasing hormone: Metabolic functions and medical applications. Front Neuroendocrinol 52 29-43.
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