The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
PIAS3 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
PIAS3 cDNA ORF Clone, Human, untagged: Synonyms
ZMIZ5 cDNA ORF Clone, Human
PIAS3 Background Information
Protein inhibitor of activated STAT3 (PIAS3) is a member of the protein inhibitor of activated STAT (PIAS) family. PIAS3 is an endogenous suppressor of signal transducer and activator of transcription 3 (STAT3) signaling and cell growth and demonstrates limited expression in the majority of human squamous cell carcinomas of the lung. By directly interacting with phosphorylated STAT3, PIAS3 can block the downstream transcriptional activity of STAT3, which is hyper-activated in various cancers. PIAS3 is the only member of the PIAS family that is indispensable for ATR activation. In response to different types of DNA damage and replication stress, PIAS3 plays multiple roles in ATR activation. STAT3 is implicated in guiding the specification of rod and cone photoreceptors through post-translational modification of key retinal transcription factors.
Successfully added to cart Please enter catalog numberSubmitted successfullyNetwork ErrorPlease enter your company namePlease enter your namePlease enter your emailPlease enter a valid email addressPlease enter some messageNot found.