PIAS3 cDNA ORF Clone, Human, untagged

Protein inhibitor of activated STAT3 (PIAS3) is a member of the protein inhibitor of activated STAT (PIAS) family. PIAS3 is an endogenous suppressor of signal transducer and activator of transcription 3 (STAT3) signaling and cell growth and demonstrates limited expression in the majority of human squamous cell carcinomas of the lung. By directly interacting with phosphorylated STAT3, PIAS3 can block the downstream transcriptional activity of STAT3, which is hyper-activated in various cancers. PIAS3 is the only member of the PIAS family that is indispensable for ATR activation. In response to different types of DNA damage and replication stress, PIAS3 plays multiple roles in ATR activation. STAT3 is implicated in guiding the specification of rod and cone photoreceptors through post-translational modification of key retinal transcription factors.

protein inhibitor of activated STAT, 3

• Apoptosis Transcription Factors and Regulators

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  Jak-Stat Signaling Pathway
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  Common G-Chain signaling pathway

• Wu CS, et al. (2016) The sumo (small ubiquitin-like modifier) ligase pias3 primes atr for checkpoint activation. J Biol Chem 291 (1): 279-290.
• He T, et al. (2018) Post-transcriptional regulation of pias3 expression by mir-18a in malignant mesothelioma. Mol Oncol 12 (12): 2124-2135.
• Dabir S, et al. (2014) Pias3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status. Int J Cancer 134 (5): 1045-1054.
• Campla CK, et al. (2017) Pias3 is necessary for dorso-ventral patterning and visual response of retinal cones but is not required for rod photoreceptor differentiation. Biol Open 6 (6): 881-890.