NFkB1/p105 cDNA ORF Clone in Cloning Vector, Human

NFKB1 (Nuclear Factor Kappa B Subunit 1) is a Protein Coding gene. This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Diseases associated with NFKB1 include Immunodeficiency, Common Variable, 12, and Common Variable Immunodeficiency. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Apoptosis Modulation and Signaling.

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

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  EGFR Signaling Pathway
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  NF-kB (NFkB) Pathway
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  B Cell Receptor Signaling Pathway
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  MAPK-Erk Pathway
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  T Cell Receptor Signaling Pathway
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  IL1 signaling pathway
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  IL17 signaling pathway

• Lougaris V, et al. (2017) Nfkb1 regulates human nk cell maturation and effector functions. Clin Immunol 175 99-108.
• Eluard B, et al. (2020) Nf-κb in the new era of cancer therapy. Trends Cancer 6 (8): 677-687.
• Dieli-Crimi R, et al. (2018) Th1-skewed profile and excessive production of proinflammatory cytokines in a nfkb1-deficient patient with cvid and severe gastrointestinal manifestations. Clin Immunol 195 49-58.