Anti-CD89 Antibody (APC)

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Anti-CD89 Antibody (APC) (Mouse Monoclonal antibody) General Information

Product name
Anti-CD89 Antibody (APC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human CD89
Immunogen
Recombinant Human CD89/FCAR Protein (Catalog#10414-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD89 / FCAR (rh CD89 / FCAR; Catalog#10414-H08H; NP_001991.1; Met 1-Asn 227) and conjugated with APC under optimum conditions, the unreacted APC was removed.
Source
Monoclonal Mouse IgG1 Clone #02
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
APC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-CD89 Antibody (APC) (Mouse Monoclonal antibody) Images

Flow cytometric analysis of anti-human CD89 on human whole blood granulocytes. The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable granulocytes.

Anti-CD89 Antibody (APC): Alternative Names

Anti-CD89 Antibody; Anti-CTB-61M7.2 Antibody; Anti-FcalphaRI Antibody; Anti-FCAR Antibody; Anti-XXbac-BPG230H20.5 Antibody

CD89 Background Information

FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.
Full Name
Fc fragment of IgA receptor
References
  • Maliszewski, C.R. et al., 1990, J. Exp. Med. 172: 1665-1672.

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