CD46 antigens

CD46 antigens general information

CD46 Gene ID 4179
CD46 Official Full Name CD46 molecule
CD46 Alias MCP, TLX
CD46 Cellular Expression T; B; NK; Endothelial; Epithelial; Granulocyte; Macrophage; Platelet
CD46 Ligand/Receptor/Association C3b, C4b, measles virus, factor I
CD46 Function Inhibitory complement activation
CD46 Summary The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

Information from NCBI or Wiki

Tips: We list all the CD antigens according to the specific name of CD molecules.