CD147 Protein

CD147 Protein Overview

CD147 reagents

Basigin is a member of the immunoglobulin (Ig) superfamily, with a structure related to the putative primordial form of the family. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition (Miyauchi et al., 1991; Kanekura et al., 1991).

CD147 protein name

Recommended name
Basigin
Aliases
CD147, EMMPRIN, EMPRIN, extracellular matrix metalloproteinase inducer, Ok blood group
Alternative name
5F7 Collagenase stimulatory factor Extracellular matrix metalloproteinase inducer EMMPRIN Leukocyte activation antigen M6 OK blood group antigen Tumor cell-derived collagenase stimulatory factor TCSF CD antigen CD147

CD147 Gene family protein

CD147 Protein Sequence

Species Human CD147 protein
Length 385
Mass (Da) 42200
Sequence Human CD147 protein sequence
Species Mouse CD147 protein
Length 389
Mass (Da) 42445
Sequence Mouse CD147 protein sequence
Species Rat CD147 protein
Length 388
Mass (Da) 42436
Sequence Rat CD147 protein sequence

CD147 Protein Molecular Weight & PI

Basigin precursor (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD147 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 22-385 Basigin.

Molecular weight (Da)

40200.97

Theoretical pI

5.33

CD147 Protein Structure

Crystal structure of the extracellular portion of HAb18G/CD147
Deposited
2007-10-26   Released:  2008-05-06
Deposition Author(s)
Yu, X.-L., Chen, Z.-N.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.8000 Å
R-Value Free
0.294
R-Value Work
0.243
3B5H From PDB

Human CD147 protein Secondary structure

CD147 Protein Interaction

Recombinant CD147 Protein Feature

CD147 Protein, Human, Recombinant (Fc Tag)

High Purity
> 97 % as determined by SDS-PAGE and SEC-HPLC Analysis.
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

Recombinant CD147 protein citations

Title
Expression of HAb18G in non-small lung cancer and characterization of activation, migration, proliferation, and apoptosis in A549 cells following siRNA-induced downregulation of HAb18G
Year
2013
Author
Xu, X;Liu, S;Lei, B;Li, W;Lin, N;Sheng, W;Huang, A;Shen, H;
Journal
Mol. Cell. Biochem.
Title
Basigin interacts with Plasmodium vivax tryptophan-rich antigen PvTRAg38 as a second erythrocyte receptor to promote parasite growth
Year
2016
Author
Rathore, S;Dass, S;Kandari, D;Kaur, I;Gupta, M;Sharma, YD;
Journal
J. Biol. Chem.
Title
Abnormal creatine transport of mutations in monocarboxylate transporter 12 (MCT12) found in patients with age-related cataract can be partially rescued by exogenous chaperone CD147
Year
2017
Author
Stäubli, A;Capatina, N;Fuhrer, Y;Munier, FL;Labs, S;Schorderet, DF;Tiwari, A;Verrey, F;Heon, E;Cheng, C;Wong, T;Berger, W;Camargo, SM;Kloeckener-Gruissem, B;
Journal
Human Molecular Genetics
Title
Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum
Year
2017
Author
Prakash, P;Zeeshan, M;Saini, E;Muneer, A;Khurana, S;Kumar Chourasia, B;Deshmukh, A;Kaur, I;Dabral, S;Singh, N;Anam, Z;Chaurasiya, A;Kaushik, S;Dahiya, P;Kalamuddin, M;Kumar Thakur, J;Mohmmed, A;Ranganathan, A;Malhotra, P;
Journal
Nat Commun
Title
Icariin influences cardiac remodeling following myocardial infarction by regulating the CD147/MMP-9 pathway
Year
2018
Author
Shi, Y;Yan, W;Lin, Q;Wang, W;
Journal
J. Int. Med. Res.

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