XPNPEP2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All XPNPEP2 reagents are produced in house and quality controlled, including 7 XPNPEP2 Antibody, 2 XPNPEP2 ELISA, 2 XPNPEP2 Gene, 1 XPNPEP2 Lysate, 1 XPNPEP2 Protein, 1 XPNPEP2 qPCR. All XPNPEP2 reagents are ready to use.

XPNPEP2 Protein (1)

    XPNPEP2 Antibody (7)

      XPNPEP2 ELISA Kit & Match Antibody ELISA Pair Set (2)

      XPNPEP2 cDNA Clone (2)

      BC126174

      In expression vector

      In lentiviral vector

      XPNPEP2 qPCR Primer (1)

      XPNPEP2 Lysate (1)

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        XPNPEP2 Background

        Aminopeptidase P (APP) is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. A membrane-bound and soluble form of this enzyme (XPNPEP2) have been identified as products of two separate genes. XPNPEP2, the X-linked gene that encodes membranous aminopeptidase P (APP), has been reported to associate with APP activity. The membrane aminopeptidase P (XPNPEP2) is largely limited in distribution to endothelia and brush border epithelia. APP and XPNPEP2 contain homologous blocks of sequence common to members of the "pita bread-fold" protein family, of which Escherichia coli methionine aminopeptidase is the prototype. The C-2399A variant in XPNPEP2 is associated with reduced APP activity and a higher incidence of AE-ACEi. XPNPEP2 mRNA was detected in fibroblasts that carry the translocation, suggesting that this gene at least partially escapes X inactivation. XPNPEP2 is a candidate gene for premature ovarian failure (POF).

        XPNPEP2 References

        • Sprinkle TJ, et al. (2000) Cloning, chromosomal sublocalization of the human soluble aminopeptidase P gene (XPNPEP1) to 10q25.3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2. Arch Biochem Biophys. 378(1): 51-6.
        • Prueitt RL, et al. (2000) Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene. Cytogenet Cell Genet. 89(1-2): 44-50.
        • Duan QL, et al. (2005) A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. Am J Hum Genet. 77(4): 617-26.
        • Woodard-Grice AV, et al. (2010) Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenet Genomics. 20(9): 532-6.

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