XIAP Proteins, Antibodies, cDNA Clones Research Reagents

XIAP (X-Linked Inhibitor Of Apoptosis) is a protein coding gene located on human chromosome Xq25. XIAP is also known as API3, ILP1, MIHA, XLP2, BIRC4, IAP-3, hIAP3 and hIAP-3. The human XIAP gene encodes a 56685 Da protein containing 497 amino acids. The XIAP protein is ubiquitously expressed in thyroid, colon and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and Cell adhesion_Plasmin signaling. XIAP is related to ligase activity and ubiquitin protein ligase activity. BIRC2 is an important paralog of XIAP gene. XIAP is associated with some diseases, including Lymphoproliferative Syndrome, X-Linked, 2 and Lymphoproliferative Syndrome, X-Linked, 1.

XIAP Protein (2)

    XIAP Antibody (2)

      XIAP cDNA Clone (32)


      In cloning vector

      In lentiviral vector

      XIAP Background

      E3 ubiquitin-protein ligase XIAP / BIRC4, also known as an inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. XIAP / BIRC4 functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. XIAP / BIRC4 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this encoding gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Thought to be the most potent apoptosis suppressor, XIAP / BIRC4, directly binds and inhibits caspases -3, -7 and -9. Survivin, which also binds to several caspases, is up-regulated in a many tumour cell types. Defects in XIAP / BIRC4 are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2). XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.

      XIAP References

      • Holcik M, et al. (2000) Functional Characterization of the X-Linked Inhibitor of Apoptosis (XIAP) Internal Ribosome Entry Site Element: Role of La Autoantigen in XIAP Translation. Mol Cell Biol. 20 (13): 4648-57.
      • Winsauer G, et al. (2008) XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2. Cell Signal. 20 (11): 2107-12.
      • Suzuki Y, et al. (2001) X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes. J Biol Chem. 276 (29): 27058-63.

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