Wnt7a, a 39Kd secreted glycoprotein composed of 349 amino acids, is a member of the Wnt family and has been reported to be involved in the carcinogenesis and progression of many types of human cancer. Wnt7a could be used as a potential diagnostic marker and target for gastric cancer (GC) management. Wnt7a is a known tumor suppressor gene in non-small cell lung cancer that regulates normal cellular proliferation and differentiation. Loss of Wnt7a expression may contribute to the carcinogenesis and tumor progression of colorectal adenocarcinoma and maybe a new prognostic marker of colorectal adenocarcinoma. WNT7A, an important ligand of Wnt/β-catenin signaling pathways, has a controversial role in tumor development.