Wnt2 Antibodies, cDNA Clones Research Reagents

WNT2 (Wnt Family Member 2, also known as IRP; INT1L1), located on 7q31.2, is a Protein Coding gene. The gene produces a 40418 Da protein composed of 360 amino acids. WNT2 showed marked similarity to the murine protooncogene Int1 and its Drosophila homolog 'wingless,' but was distinct from the human WNT1 gene. Like WNT1, WNT2 appears to be a secreted protein; it is cysteine-rich with a signal peptide sequence and has 2 potential Asn-linked glycosylation sites. WNT2 acts as a pro-angiogenic factor in placental vascularization and increases angiogenesis in liver sinusoidal endothelial cells (ECs) and other ECs.

Wnt2 Antibody (1)

    Wnt2 cDNA Clone (13)

    NM_003391.2

    Wnt2 Background

    WNT2 gene on human chromosome 7q31 is a paralog of the WNT2B gene on human chromosome 1p13. Rat Wnt2 gene was identified within the rat genome draft sequence AC095247.4. Human WNT2 showed 96.4% total-amino-acid identity with rat Wnt2, 96.1% with mouse Wnt2, 68.6% with zebrafish wnt2, and 67.8% with fugu wnt2. WNT2 is an evolutionarily conserved secreted-type glycoprotein belonging to the WNT family. WNT2 mRNA is expressed in human fetal lung and placenta, but almost undetectable in the normal gastrointestinal tract. WNT2 acts as a pro-angiogenic factor in placental vascularization and increases angiogenesis in liver sinusoidal endothelial cells (ECs) and other ECs. Increased WNT2 expression is detectable in many carcinomas and participates in tumor progression. In human colorectal cancer (CRC), WNT2 is selectively elevated in cancer-associated fibroblasts (CAFs), leading to increased invasion and metastasis.

    Wnt2 References

    • Unterleuthner D, et al. (2020) Cancer-associated fibroblast-derived wnt2 increases tumor angiogenesis in colon cancer. Angiogenesis 23 (2): 159-177.
    • Katoh M (2003) Wnt2 and human gastrointestinal cancer (review). Int J Mol Med 12 (5): 811-816.
    • Katoh M (2001) Frequent up-regulation of wnt2 in primary gastric cancer and colorectal cancer. Int J Oncol 19 (5): 1003-1007.

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