Vitronectin Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

VTN (Vitronectin) is a protein coding gene located on human chromosome 17q11.2. VTN is also known as VN, V75 and VNT. The human VTN gene encodes a 54306 Da protein containing 478 amino acids. The VTN protein is restrictedly expressed toward liver. Among its related pathways are Degradation of the extracellular matrix and amb2 Integrin signaling. VTN is related to heparin binding and scavenger receptor activity. PRG4 is an important paralog of VTN gene. VTN is associated with some diseases, including Glanzmann Thrombasthenia and Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome.

Vitronectin Protein (2)

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      Vitronectin ELISA Kit & Match Antibody ELISA Pair Set (2)

      Vitronectin cDNA Clone (39)


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        Vitronectin Background

        Vitronectin, also known as VTN, is a member of the pexin family. It is an abundant glycoprotein found in serum the extracellular matrix and promotes cell adhesion and spreading. Vitronectin is a secreted protein and exists in either a single chain form or a cleaved, two chain form held together by a disulfide bond. Vitronectin is a plasma glycoprotein implicated as a regulator of diverse physiological process, including blood coagulation, fibrinolysis, pericellular proteolysis, complement dependent immune responses, and cell attachment and spreading. Because of its ability to bind platelet glycoproteins and mediate platelet adhesion and aggregation at sites of vascular injury, vitronectin has become an important mediator in the pathogenesis of coronary atherosclerosis. As a multifunctional protein with a multiple binding domain, Vitronectin interacts with a variety of plasma and cell proteins. Vitronectin binds multiple ligands, including the soluble vitronectin receptor. It may be an independent predictor of adverse cardiovascular outcomes following acute stenting. Accordingly, Vitronectin is suggested to be involved in hemostasis, cell migration, as well as tumor malignancy.

        Vitronectin References

        • Ekmeki OB, et al. (2006) Vitronectin in atherosclerotic disease. Clin Chim Acta. 368(1-2): 77-83.
        • Derer W, et al. (2009) Vitronectin concentrations predict risk in patients undergoing coronary stenting. Circ Cardiovasc Interv. 2(1): 14-9.
        • Heyman L, et al. (2010) Mesothelial vitronectin stimulates migration of ovarian cancer cells. Cell Biol Int. 34(5): 493-502.

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