Vinculin Proteins, Antibodies, cDNA Clones Research Reagents

VCL (Vinculin) is a protein coding gene located on human chromosome 10q22.2. VCL is also known as MV, MVCL, CMD1W, CMH15, and HEL114. The human VCL gene encodes a 123799 Da protein containing 1134 amino acids. The VCL protein is ubiquitously expressed in endometrium, prostate and other tissues. Among its related pathways are RET signaling and Paradoxical activation of RAF signaling by kinase inactive BRAF. VCL is related to actin binding and ubiquitin protein ligase binding. CTNNA1 is an important paralog of VCL gene. VCL is associated with some diseases, including Cardiomyopathy, Dilated, 1W and Cardiomyopathy, Familial Hypertrophic, 15.

Vinculin Protein (2)

    Vinculin Antibody (2)

      Vinculin cDNA Clone (30)

      Vinculin Lysate (2)

        More Product Popular With Customers

        Vinculin Background

        Vinculin (VCL) is a cytoskeletal protein that is closely related to both cell-matrix interactions and cell-cell junctions. VCL is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. The protein contains an acidic N-terminal domain and a basic C-terminal domain separated by a proline-rich middle segment. This protein has multi-ligand properties and has been found to interact with a number of microfilament associated proteins, such as talin, a-actinin, and paxillin, which reportedly bind to either the head or tail domains of vinculin.

        Vinculin References

        • Massoumi R, et al. (2001) Leukotriene D(4) affects localisation of vinculin in intestinal epithelial cells via distinct tyrosine kinase and protein kinase C controlled events. J Cell Sci. 114(10): 1925-34.
        • Turner CE, et al. (1994) Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region. J Cell Sci. 107 (6): 1583-91.
        • Strasser P, et al. (1993) Variable and constant regions in the C-terminus of vinculin and metavinculin: cloning and expression of fragments in E. coli. FEBS Lett. 317: 189-194.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.