Vinculin Proteins, Antibodies, cDNA Clones Research Reagents

All Vinculin reagents are produced in house and quality controlled, including 2 Vinculin Antibody, 30 Vinculin Gene, 1 Vinculin IP Kit, 2 Vinculin Lysate, 2 Vinculin Protein, 2 Vinculin qPCR. All Vinculin reagents are ready to use.

Vinculin Protein (2)

    Vinculin Antibody (2)

      Vinculin cDNA Clone (30)

      Vinculin Lysate (2)

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        Vinculin Background

        Vinculin (VCL) is a cytoskeletal protein that is closely related to both cell-matrix interactions and cell-cell junctions. VCL is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. The protein contains an acidic N-terminal domain and a basic C-terminal domain separated by a proline-rich middle segment. This protein has multi-ligand properties and has been found to interact with a number of microfilament associated proteins, such as talin, a-actinin, and paxillin, which reportedly bind to either the head or tail domains of vinculin.

        Vinculin References

        • Massoumi R, et al. (2001) Leukotriene D(4) affects localisation of vinculin in intestinal epithelial cells via distinct tyrosine kinase and protein kinase C controlled events. J Cell Sci. 114(10): 1925-34.
        • Turner CE, et al. (1994) Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region. J Cell Sci. 107 (6): 1583-91.
        • Strasser P, et al. (1993) Variable and constant regions in the C-terminus of vinculin and metavinculin: cloning and expression of fragments in E. coli. FEBS Lett. 317: 189-194.

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