Vimentin Proteins, Antibodies, cDNA Clones Research Reagents

VIM (Vimentin) is a protein coding gene located on human chromosome 10p13. The human VIM gene encodes a 53652 Da protein containing 466 amino acids. The VIM protein is ubiquitously expressed in ovary, fat and other tissues. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Apoptosis and survival Caspase cascade. VIM is related to identical protein binding and protein C-terminus binding. DES is an important paralog of VIM gene. VIM is associated with some diseases, including Cataract 30, Multiple Types and Cataract 30.

Vimentin Protein (1)

    Vimentin Antibody (5)

      Vimentin cDNA Clone (24)

      NM_003380.2

      In lentiviral vector

      NM_031140.1

      In cloning vector

      In lentiviral vector

      Vimentin Lysate (1)

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        Vimentin Background

        Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers compose the basic subunit of vimentin assembly. Vimentin is crucial for supporting and anchoring the position of the organelles in the cytosol. Vimentin provided cells with a resilience absent from the microtubule or actin filament networks, when under mechanical stress in vivo. Therefore, in general, it is accepted that vimentin is the cytoskeletal component responsible for maintaining cell integrity. Vimentin is also responsible for stabilizing cytoskeletal interactions. It is found that vimentin control the transport of low-density lipoprotein. It has been used as a sarcoma tumor marker to identify mesenchyme.

        Vimentin References

        • Russell RL, et al. (2001) Uridine phosphorylase association with vimentin. Intracellular distribution and localization. J Biol Chem. 276(16):13302-7.
        • Moinova, et al. (2012) Aberrant Vimentin Methylation is Characteristic of Upper GI Pathologies. Cancer Epidemiology Biomarkers Prev. 21(4):594-600.
        • Leader M, et al. (1987) Vimentin: an evaluation of its role as a tumour marker. Histopathology. 11(1):63-72.

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