VCAM1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All VCAM1 reagents are produced in house and quality controlled, including 17 VCAM1 Antibody, 2 VCAM1 ELISA, 52 VCAM1 Gene, 1 VCAM1 IP Kit, 5 VCAM1 Lysate, 6 VCAM1 Protein, 3 VCAM1 qPCR. All VCAM1 reagents are ready to use.

VCAM1 Protein (6)

    VCAM1 Antibody (17)

      VCAM1 ELISA Kit & Match Antibody ELISA Pair Set (2)

      VCAM1 cDNA Clone (52)

      NM_001078.2
      NM_011693.3
      NM_012889.1
      XM_004812161.1

      VCAM1 Lysate (5)

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        VCAM1 Background

        Vascular cell adhesion molecule 1 (VCAM-1), also known as CD16, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.

        VCAM1 References

        • Cook-Mills JM. (2002) VCAM-1 signals during lymphocyte migration: role of reactive oxygen species. Mol Immunol. 39(9): 499-508.
        • Preiss DJ, et al. (2007) Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis? Int J Clin Pract. 61(4): 697-701.

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