VCAM1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

VCAM1 (Vascular Cell Adhesion Molecule 1) is a protein coding gene located on human chromosome 1p21.2. VCAM1 is also known as CD106 and INCAM-100. The human VCAM1 gene encodes an 81276 Da protein containing 739 amino acids. The VCAM1 protein is biasedly expressed in spleen, lymph node and other tissues. Among its related pathways are Degradation of the extracellular matrix and Cellular roles of Anthrax toxin. VCAM1 is related to integrin binding and primary amine oxidase activity. MXRA5 is an important paralog of VCAM1 gene. VCAM1 is associated with some diseases, including Viral Encephalitis and Chronic Venous Insufficiency.

VCAM1 Protein (6)

    VCAM1 Antibody (22)

      VCAM1 ELISA Kit & Match Antibody ELISA Pair Set (2)

      VCAM1 cDNA Clone (52)

      NM_001078.2
      NM_011693.3
      NM_012889.1
      XM_004812161.1

      VCAM1 Lysate (5)

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        VCAM1 Background

        Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.

        VCAM1 References

        • Cook-Mills JM. (2002) VCAM-1 signals during lymphocyte migration: role of reactive oxygen species. Mol Immunol. 39(9): 499-508.
        • Preiss DJ, et al. (2007) Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis? Int J Clin Pract. 61(4): 697-701.

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