VAV1 Antibodies, cDNA Clones Research Reagents

VAV1 (Vav Guanine Nucleotide Exchange Factor 1) is a protein coding gene located on human chromosome 19p13.3. VAV1 is also known as VAV. The human VAV1 gene encodes a 98314 Da protein containing 845 amino acids. The VAV1 protein is broadly expressed in lymph node, appendix and other tissues. Among its related pathways are RET signaling and Signaling by GPCR. VAV1 is related to DNA-binding transcription factor activity and Rho guanyl-nucleotide exchange factor activity. VAV3 is an important paralog of VAV1 gene. VAV1 is associated with some diseases, including Wiskott-Aldrich Syndrome and Angioimmunoblastic T-Cell Lymphoma.

VAV1 Antibody (2)

    VAV1 cDNA Clone (1)


    In expression vector

    VAV1 Background

    VAV1, short for vav guanine nucleotide exchange factor 1, is normally expressed exclusively in the hematopoietic system, where it functions as a specific GDP/GTP nucleotide exchange factor (GEF), strictly regulated by tyrosine phosphorylation. Vav1 contains many characteristic structural motifs important for its function as a versatile signal transducer. In hematopoietic cells, Vav1 is phosphorylated following cell surface receptor activation, triggering re-organization of the cytoskeleton and regulation of other cellular functions including transcription, cytokine production, cell cycle progression, and Ca(2+) mobilization.

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