UCHL3 Proteins, Antibodies, cDNA Clones Research Reagents

UCHL3 (Ubiquitin C-Terminal Hydrolase L3) is a protein coding gene located on human chromosome 13q22.2. UCHL3 is also known as UCH-L3. The human UCHL3 gene encodes a 26183 Da protein containing 230 amino acids. The UCHL3 protein is ubiquitously expressed in thyroid, testis and other tissues. Among its related pathways are Neuroscience and Metabolism of proteins. UCHL3 is related to peptidase activity and ubiquitin binding. UCHL1 is an important paralog of UCHL3 gene.

UCHL3 Protein (3)

    UCHL3 Antibody (12)

      UCHL3 cDNA Clone (45)

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      UCHL3 Background

      Ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as UCH-L3, Ubiquitin thioesterase L3 and UCHL3, is a ubiquitin-protein hydrolase that belongs to the peptidase C12 family. It is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCHL3 is highly expressed in heart, skeletal muscle, and testis. UCHL1 and UCHL3 are two of the deubiquitinating enzymes expressed in the brain. These phenotypes indicate the importance of UCHL1 and UCHL3 in the regulation of the central nervous system. UCHL3 functions as a de-ubiquitinating enzyme where lack of its hydrolase activity may result in the prominent accumulation of ubiquitinated proteins and subsequent induction of stress responses in skeletal muscle. UCHL3 has also been identified as a tumor-specific antigen in colon cancer.

      UCHL3 References

      • Wood,M.A. et al., 2005, Hippocampus  15 (5):610-21.
      • Kwon,J. et al., 2006, Exp Anim  55 (1):35-43.
      • Setsuie,R. et al., 2009, Neurochem Int  54 (5-6):314-21.
      • Setsuie,R. et al., 2010, Neurochem Int  56 (8):911-8.

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