UCHL1 Proteins, Antibodies, cDNA Clones Research Reagents

UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a protein coding gene located on human chromosome 4p13. UCHL1 is also known as NDGOA, PARK5, PGP95, SPG79, PGP9.5, Uch-L1, HEL-117, PGP 9.5 and HEL-S-53. The human UCHL1 gene encodes a 24824 Da protein containing 223 amino acids. Biased expression in brain (RPKM 389.7), adrenal (RPKM 70.8) and 2 other tissues Among its related pathways are Neuroscience and Hepatitis C and Hepatocellular Carcinoma. UCHL1 is related to ligase activity and cysteine-type endopeptidase activity. UCHL3 is an important paralog of UCHL1 gene. UCHL1 is associated with some diseases, including Spastic Paraplegia 79, Autosomal Recessive and Parkinson Disease 5, Autosomal Dominant.

UCHL1 Protein (3)

    UCHL1 Antibody (11)

      More Product Popular With Customers

      UCHL1 Background

      Ubiquitin carboxyl-terminal hydrolase isozyme L1, also known as UCH-L1, Ubiquitin thioesterase L1, PGP9.5 and UCHL1, is a deubiqutinating enzyme with important functions in recycling of ubiquitin. Regulated proteolysis by the ubiquitin pathway has been implicated in control of the cell cycle, transcriptional activation, cell fate and growth, and synaptogenesis. The ubiquitin-proteasome system is involved in synaptic plasticity and is proposed to be part of a molecular switch that converts short-term synaptic potentiation to long-term changes in synaptic strength. UCHL1 is found in neuronal cell bodies and processes throughout the neocortex (at protein level). It is expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. UCHL1 is weakly expressed in ovary. UCHL1 is a ubiquitin-protein hydrolase. It is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity. UCHL1 dysfunction has been associated with neurodegeneration in Parkinson's, Alzheimer's, and Huntington's disease patients. Reduced UCHL1 function may jeopardize the survival of CNS neurons.

      UCHL1 References

      • Wada H., et al., 1998, Biochem. Biophys. Res. Commun. 251:688-92.
      • Choi J., et al., 2004, J. Biol. Chem. 279:13256-64.
      • Lombardino,A.2005, et al., J.Proc Natl Acad Sci.USA102 (22):8036-41
      • Okochi-Takada,E. et al., 2006, Int J Cancer. 119 (6):1338-44.
      • Zetterberg, M. et al., 2010, Mol Neurodegener  5 :11.

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.