TWEAK/TNFSF12 Proteins, cDNA Clones Research Reagents

TNFSF12 (TNF Superfamily Member 12) is a protein coding gene located on human chromosome 17p13.1. TNFSF12 is also known as APO3L, DR3LG, TWEAK and TNLG4A. The human TNFSF12 gene encodes a 27216 Da protein containing 249 amino acids. The TNFSF12 protein is ubiquitously expressed in fat, lung and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and PEDF Induced Signaling. TNFSF12 is related to signaling receptor binding and tumor necrosis factor receptor binding. TNFSF12-TNFSF13 is an important paralog of TNFSF12 gene. TNFSF12 is associated with some diseases, including Common Variable Immunodeficiency and Amnestic Disorder.

TWEAK/TNFSF12 Protein (4)

TWEAK/TNFSF12 cDNA Clone (65)


TWEAK/TNFSF12 Lysate (4)

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    TWEAK/TNFSF12 Background

    TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.

    TWEAK/TNFSF12 References

    • Wiley SR, et al. (2004) TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. Cytokine Growth Factor Rev. 14(3-4):241-9.
    • Campbell S, et al. (2006) The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity. Front Biosci. 9:2273-84.
    • Lynch CN, et al. (1999) TWEAK induces angiogenesis and proliferation of endothelial cells. J Biol Chem. 274(13):8455-9.

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