TROY Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TNFRSF19 (TNF Receptor Superfamily Member 19) is a protein coding gene located on human chromosome 13q12.12. TNFRSF19 is also known as TAJ, TROY, TRADE and TAJ-alpha. The human TNFRSF19 gene encodes a 46015 Da protein containing 423 amino acids. The TNFRSF19 protein is biasedly expressed in skin, prostate and other tissues. Among its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and PEDF Induced Signaling. TNFRSF19 is related to tumor necrosis factor-activated receptor activity. EDA2R is an important paralog of TNFRSF19 gene. TNFRSF19 is associated with some diseases, including Ovarian Cancer and Ectodermal Dysplasia.

TROY Protein (5)

    TROY Antibody (7)

      TROY ELISA Kit & Match Antibody ELISA Pair Set (2)

      TROY cDNA Clone (39)


      TROY Lysate (5)

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        TROY Background

        Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), also known as TAJ-alpha or TROY, is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the ductal epithelium of the prostate and parotid glands. TNFRSF19/TROY expression is detected in some adenocarcinoma cell lines that arise from this tissue. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. TNFRSF19/TROY is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. TNFRSF19/TROY was negatively regulated by adipogenic transcription factor CCAAT/enhancer-binding proteins (C/EBP). TNFRSF19 signals activation of the Jnk pathway and induces cell death. Overexpression of TNFRSF19 also signals NFB activation, comparable and similar to that by p75NGFR. TNFRSF19/TROY is capable of activating key signaling pathways of the TNF receptor family, and its predominant expression patterns suggest that it plays a role in the growth and regulation of epithelial tissues.

        TROY References

        • Hu S, et al. (1999) Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily. Genomics. 62(1): 103-7.
        • Qiu W, et al. (2010) Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical Wnt signaling and C/EBP. J Biol Chem. 285(19): 14438-49.
        • Hisaoka T, et al. (2006) Characterization of TROY/TNFRSF19/TAJ-expressing cells in the adult mouse forebrain. Brain Res. 1110(1): 81-94.

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