TROP2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TACSTD2 (Tumor Associated Calcium Signal Transducer 2) is a protein coding gene located on human chromosome 1p32.1. TACSTD2 is also known as EGP1, GP50, M1S1, EGP-1, TROP2, GA7331 and GA733-1. The human TACSTD2 gene encodes a 35709 Da protein containing 323 amino acids. Among its related pathways are Ca, cAMP and Lipid Signaling and Adhesion. EPCAM is an important paralog of TACSTD2 gene. TACSTD2 is associated with some diseases, including Corneal Dystrophy, Gelatinous Drop-Like and Lattice Corneal Dystrophy.

TROP2 Protein (8)

    TROP2 Antibody (19)

      TROP2 ELISA Kit & Match Antibody ELISA Pair Set (2)

      TROP2 cDNA Clone (39)

      NM_002353.2
      NM_020047.3
      NM_001009540.2
      XM_005543235.2

      In expression vector

      TROP2 Lysate (8)

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        TROP2 Background

        TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.

        TROP2 References

        • Ripani E, et al. (1998) Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 76(5): 671-6.
        • Wang J, et al. (2008) Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther. 7(2): 280-5.

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