TRIB3 Proteins, Antibodies, cDNA Clones Research Reagents

TRIB3 (Tribbles Pseudokinase 3) is a protein coding gene located on human chromosome 20p13. TRIB3 is also known as NIPK, SINK, TRB3, SKIP3, and C20orf97. The human TRIB3 gene encodes a 39578 Da protein containing 358 amino acids. The TRIB3 protein is broadly expressed in thyroid, liver and other tissues. Among its related pathways are RET signaling and CD28 co-stimulation. TRIB3 is related to transferase activity, transferring phosphorus-containing groups and protein kinase binding. TRIB1 is an important paralog of TRIB3 gene. TRIB3 is associated with Diabetes Mellitus, Noninsulin-Dependent.

TRIB3 Protein (1)

    TRIB3 Antibody (1)

      TRIB3 cDNA Clone (30)

      TRIB3 Lysate (1)

        TRIB3 Background

        Tribbles homolog 3, also known as Neuronal cell death-inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, SINK and TRIB3, is a Nucleus protein that belongs to the protein kinase superfamily and CAMK Ser/Thr protein kinase family and Tribbles subfamily. Highest expression Of TRIB3 is in liver, pancreas, peripheral blood leukocytes and bone marrow. It is also highly expressed in a number of primary lung, colon and breast tumors. TRIB3 is expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney. TRIB3 disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. TRIB3 may bind directly to and mask the 'Thr-38' phosphorylation site in AKT1. It binds to ATF4 and inhibits its transcriptional activation activity. TRIB3 interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. It interacts with MAPK kinases and regulates activation of MAP kinases. It may play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. TRIB3 does not display kinase activity.

        TRIB3 References

        • Wu M. et al., 2003, J. Biol. Chem. 278: 27072-9.
        • Kiss-Toth E. et al., 2004, J. Biol. Chem. 279: 42703-8.
        • Ord D., et al.,2005, Biochem. Biophys. Res. Commun. 330: 210-8.
        • Schwarzer R. et al., 2006, Cell. Signal. 18:899-909.
        • Greenman C. et al., 2007, Nature. 446:153-8.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.