TREM-2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TREM2 (Triggering Receptor Expressed On Myeloid Cells 2) is a protein coding gene located on human chromosome 6p21.1. TREM2 is also known as PLOSL2, TREM-2, Trem2a, Trem2b, and Trem2c. The human TREM2 gene encodes a 25447 Da protein containing 230 amino acids. The TREM2 protein is broadly expressed in brain, lung and other tissues. Among its related pathways are Neuroscience and RET signaling. TREM2 is related to lipopolysaccharide binding. CD300A is an important paralog of TREM2 gene. TREM2 is associated with some diseases, including Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 2 and Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1.

TREM-2 Protein (3)

    TREM-2 Antibody (7)

      TREM-2 ELISA Kit & Match Antibody ELISA Pair Set (2)

      TREM-2 cDNA Clone (26)


      TREM-2 Lysate (3)

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        TREM-2 Background

        Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary.

        TREM-2 References

        • Bouchon, A. et al., 2000, J. Immunol. 164: 4991-4995.
        • Paloneva, J. et al., 2002, Am. J. Hum. Genet. 71:656-662. 
        • Prada, I. et al., 2006, Neuroscience. 140 (4): 1139-48.
        • Neumann, H. et al., 2007, J Neuroimmunol. 184 (1-2): 92-9.
        • Thrash, JC. et al., 2009, Neurochem Res. 34 (1): 38-45.

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