TRAIL/TNFSF10 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TNFSF10 (TNF Superfamily Member 10) is a protein coding gene located on human chromosome 3q26.31. TNFSF10 is also known as TL2, APO2L, CD253, TRAIL, Apo-2L and TNLG6A. The human TNFSF10 gene encodes a 32509 Da protein containing 281 amino acids. The TNFSF10 protein is ubiquitously expressed in lung, placenta and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and Signaling by GPCR. TNFSF10 is related to signaling receptor binding and tumor necrosis factor receptor binding. TNFSF11 is an important paralog of TNFSF10 gene. TNFSF10 is associated with some diseases, including Thoracic Cancer and Ameloblastoma.

TRAIL/TNFSF10 Protein (3)

    TRAIL/TNFSF10 Antibody (7)

      TRAIL/TNFSF10 ELISA Kit & Match Antibody ELISA Pair Set (1)

      TRAIL/TNFSF10 cDNA Clone (66)


      TRAIL/TNFSF10 Background

      Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF10 / Apo-2L / CD253 functions as a ligand that induces the process of cell death called apoptosis. TNFSF10 / TRAIL shows homology to other members of the tumor necrosis factor superfamily. As one member of the cluster of differentiation system, TNFSF10 / CD253 is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion TNFSF10 / Apo-2L / CD253 / TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A / TRAILR1, TNFRSF10B / TRAILR2, TNFRSF10C / TRAILR3, TNFRSF10D / TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of TNFSF10 / TRAIL may be modulated by binding to the decoy receptors TNFRSF10C / TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8 / JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

      TRAIL/TNFSF10 References

      • Song C, et al. (2005) TRAIL (CD253), a new member of the TNF superfamily. J Biol Regul Homeost Agents. 19(1-2): 73-7.
      • Kuribayashi K, et al. (2008) TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death. Cancer Biol Ther. 7(12): 2034-8.
      • Wiley SR, et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 3(6): 673-82.

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.