TRAF6 Antibodies, cDNA Clones Research Reagents

TRAF6 (TNF Receptor Associated Factor 6) is a protein coding gene located on human chromosome 11p12. TRAF6 is also known as RNF85 and MGC:3310. The human TRAF6 gene encodes a 59573 Da protein containing 522 amino acids. The TRAF6 protein is ubiquitously expressed in bone marrow, thyroid and other tissues. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and B cell receptor signaling pathway (KEGG). TRAF6 is related to identical protein binding and ligase activity. TRAF2 is an important paralog of TRAF6 gene. TRAF6 is associated with some diseases, including Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant and Streptococcus Pneumonia.

TRAF6 Antibody (1)

    TRAF6 cDNA Clone (5)

    NM_145803.2

    In expression vector

    In lentiviral vector

    NM_001303273.1

    In expression vector

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    TRAF6 Background

    Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an essential component of the signaling complex that mediates osteoclastogenesis. As an adaptor protein of E3 ligase function, TRAF6 regulates NF-kappaB signaling via TAK1 and I-kappaB kinase (IKK) activation. TRAF6 (TNF receptor associated factor 6) plays a pivotal role in NFKB activation and macroautphagy/autophagy activation induced by TLR4 (toll-like receptor 4) signaling. TRAF6 is one of the key adapter molecules in Toll-like receptor signal transduction that triggers downstream cascades involved in innate immunity.

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