TPK1 Proteins, Antibodies, cDNA Clones Research Reagents

TPK1 (Thiamin Pyrophosphokinase 1) is a protein coding gene located on human chromosome 7q35. TPK1 is also known as PP20, HTPK1 and THMD5. The human TPK1 gene encodes a 27265 Da protein containing 243 amino acids. The TPK1 protein is ubiquitously expressed in duodenum, testis and other tissues. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Thiamine metabolism. TPK1 is related to kinase activity and thiamine binding. TPK1 is associated with some diseases, including Thiamine Metabolism Dysfunction Syndrome 5 and Megaloblastic Anemia.

TPK1 Protein (1)

    TPK1 Antibody (3)

      TPK1 cDNA Clone (30)

      TPK1 qPCR Primer (1)

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      TPK1 Background

      Thiamine pyrophosphokinase (TPK) produces thiamine pyrophosphate, a cofactor for a number of enzymes, including pyruvate dehydrogenase and 2-ketoglutarate dehydrogenase. Episodic encephalopathy type thiamine metabolism dysfunction (OMIM 614458) due to TPK1 mutations is a recently described rare disorder. The genomic variations in the fetal and maternal TPK1 gene could contribute to the variability of birth weight in normal humans.

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