TNF-alpha Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TNF (Tumor Necrosis Factor) is a protein coding gene located on human chromosome 6p21.33. TNF is also known as DIF, TNFA, TNFSF2, TNLG1F, and TNF-alpha. The human TNF gene encodes a 25644 Da protein containing 233 amino acids. The TNF protein is biasedly expressed in bone marrow, lymph node and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and Monoamine Transport. TNF is related to identical protein binding and cytokine activity. LTB is an important paralog of TNF gene. TNF is associated with some diseases, including Asthma and Malaria.

TNF-alpha Antibody (38)

    TNF-alpha ELISA Kit & Match Antibody ELISA Pair Set (4)

    TNF-alpha cDNA Clone (78)

    NM_000594.2
    NM_013693.2
    NM_012675.3
    NM_001047149.1
    NM_001003244.4
    EF368211.1

    TNF-alpha Lysate (1)

      TNF-alpha Background

      Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.

      TNF-alpha Protein & Antibody

      TNF-alpha References

      • Hector J, et al. (2007) TNF-alpha alters visfatin and adiponectin levels in human fat. Horm Metab Res. 39(4): 250-5.
      • Berthold-Losleben M, et al. (2008) The TNF-alpha System: Functional Aspects in Depression, Narcolepsy and Psychopharmacology. Curr Neuropharmacol. 6(3): 193-202.

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