TLR8 cDNA Clones Research Reagents

TLR8 (Toll Like Receptor 8) is a protein coding gene located on human chromosome Xp22.2. TLR8 is also known as CD288. The human TLR8 gene encodes a 119828 Da protein containing 1041 amino acids. The TLR8 protein is biasedly expressed in appendix, spleen and other tissues. Among its related pathways are NF-KappaB Family Pathway and Diseases associated with the TLR signaling cascade. TLR8 is related to RNA binding and drug binding. TLR7 is an important paralog of TLR8 gene. TLR8 is associated with some diseases, including Superficial Basal Cell Carcinoma and Crimean-Congo Hemorrhagic Fever.

TLR8 cDNA Clone (15)

BC101075

In expression vector

In lentiviral vector

NM_001130427.1

TLR8 qPCR Primer (1)

TLR8 Background

TLR8 polymorphism was associated with protective immunity elicited by vaccination with bacillus Calmette-Guerin (BCG) in a human cohort. That TLR8 as an important driver of TFH cell differentiation and a promising target for TFH cell-skewing vaccine adjuvants. Toll-like receptor (TLR)7/8 plays a crucial role in host recognition/response to viruses and its mucosal expression directly correlates with intestinal inflammation. Toll-like receptor 8 (TLR8) is an important component of the human innate immune system that recognizes single-stranded RNA (ssRNA).

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