TLR4 Proteins, Antibodies, cDNA Clones Research Reagents

TLR4 (Toll Like Receptor 4) is a protein coding gene located on human chromosome 9q33.1. TLR4 is also known as TOLL, CD284, TLR-4 and ARMD10. The human TLR4 gene encodes a 95680 Da protein containing 839 amino acids. The TLR4 protein is broadly expressed in spleen, appendix and other tissues. Among its related pathways are Antigen processing-Cross presentation and Activated TLR4 signalling. TLR4 is related to lipopolysaccharide binding. TLR5 is an important paralog of TLR4 gene. TLR4 is associated with some diseases, including Pertussis and Pyelonephritis.

TLR4 Protein (1)

    TLR4 Antibody (1)

      TLR4 cDNA Clone (52)


      TLR4 Lysate (1)

        TLR4 Background

        TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. TLR 4 has also been designated as CD284 (cluster of differentiation 284). It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). It acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. It is also involved in LPS-independent inflammatory responses triggered by Ni(2+).

        TLR4 References

        • Re, Fabio, et al. (2002) Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness. J Biol Chem. 277(26):23427-32.
        • Shimazu, R, et al. (1999) MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4. J Exp Med. 189(11):1777-82.
        • Blanco, A M, et al. (2005) Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes. Journal of immunology. 175(10):6893-9.

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