TLR3 Proteins, Antibodies, cDNA Clones Research Reagents

TLR3 (Toll Like Receptor 3) is a protein coding gene located on human chromosome 4q35.1. TLR3 is also known as CD283 and IIAE2. The human TLR3 gene encodes a 103829 Da protein containing 904 amino acids. The TLR3 protein is ubiquitously expressed in duodenum, small intestine and other tissues. Among its related pathways are NF-KappaB Family Pathway and Activated TLR4 signalling. TLR3 is related to identical protein binding and transmembrane signaling receptor activity. TLR7 is an important paralog of TLR3 gene. TLR3 is associated with some diseases, including Encephalopathy, Acute, Infection-Induced 2 and Human Immunodeficiency Virus Type 1.

TLR3 Protein (2)

    TLR3 Antibody (5)

      TLR3 cDNA Clone (40)


      In cloning vector


      TLR3 Lysate (2)

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        TLR3 Background

        Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3/CD283 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 is a nucleotide-sensing TLR that is activated by double-stranded RNA, a sign of viral infection. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses.

        TLR3 References

        • Muzio M, et al.. (2000) Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol. 164(11): 5998-6004.
        • Doyle S, et al.. (2002) IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity. 17(3): 251-63.
        • Choe J, et al.. (2005) Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science. 309(5734): 581-5.

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