TLR2 Proteins, Antibodies, cDNA Clones Research Reagents

TLR2 (Toll Like Receptor 2) is a protein coding gene located on human chromosome 4q31.3. TLR2 is also known as TIL4 and CD282. The human TLR2 gene encodes an 89838 Da protein containing 784 amino acids. The TLR2 protein is broadly expressed in appendix, bone marrow and other tissues. Among its related pathways are Antigen processing-Cross presentation and Activated TLR4 signalling. TLR2 is related to protein heterodimerization activity and transmembrane signaling receptor activity. TLR6 is an important paralog of TLR2 gene. TLR2 is associated with some diseases, including Leprosy 3 and Colorectal Cancer.

TLR2 Protein (3)

    TLR2 Antibody (6)

      TLR2 cDNA Clone (42)


      In cloning vector

      In lentiviral vector

      In expression vector


      TLR2 Lysate (3)

        TLR2 Background

        TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathogen recognition and activation of innate immunity. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR2 contains 14 LRR (leucine-rich) repeats and 1 TIR domain. TLR2 gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. CD282 cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. It also cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. CD282 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. It may also promote apoptosis in response to lipoproteins.

        TLR2 References

        • Do KN, et al. (2012) TLR2 controls intestinal carcinogen detoxication by CYP1A1. PLoS ONE. 7 (3): e32309.
        • Dziarski R, et al. (2001) Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes. J Endotoxin Res. 6 (5): 401-5.
        • Lorenz E, (2007) TLR2 and TLR4 expression during bacterial infections. Curr Pharm Des. 12 (32): 4185-93.

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