TL1A Proteins, cDNA Clones Research Reagents

TNFSF15 (TNF Superfamily Member 15) is a protein coding gene located on human chromosome 9q32. TNFSF15 is also known as TL1, TL1A, VEGI, TNLG1B, and VEGI192A. The human TNFSF15 gene encodes a 28087 Da protein containing 251 amino acids. The TNFSF15 protein is broadly expressed in duodenum, urinary bladder and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. TNFSF15 is related to signaling receptor binding and tumor necrosis factor receptor binding. TNF is an important paralog of TNFSF15 gene. TNFSF15 is associated with some diseases, including Primary Biliary Cirrhosis and Diverticulitis.

TL1A Protein (5)

    TL1A cDNA Clone (29)


    In cloning vector

    In lentiviral vector


    In cloning vector

    TL1A qPCR Primer (1)

    TL1A Lysate (5)

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      TL1A Background

      TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.

      TL1A References

      • Jin T, et al. (2007) X-ray crystal structure of TNF ligand family member TL1A at 2.1A. Biochem Biophys Res Commun. 364(1):1-6.
      • Cassatella MA, et al. (2007) Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis. J Immunol. 178(11):7325-33
      • Prehn JL, et al. (2007) The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells. J Immunol. 178(7):4033-8.

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