TIMP2 Proteins, cDNA Clones Research Reagents

TIMP2 (TIMP Metallopeptidase Inhibitor 2) is a protein coding gene located on human chromosome 17q25.3. TIMP2 is also known as DDC8 and CSC-21K. The human TIMP2 gene encodes a 24399 Da protein containing 220 amino acids. The TIMP2 protein is ubiquitously expressed in ovary, endometrium and other tissues. Among its related pathways are Degradation of the extracellular matrix and NF-KappaB Family Pathway. TIMP2 is related to integrin binding and enzyme activator activity. TIMP4 is an important paralog of TIMP2 gene. TIMP2 is associated with some diseases, including Conjunctivochalasis and Sorsby Fundus Dystrophy.

TIMP2 Protein (2)

    TIMP2 cDNA Clone (26)


    TIMP2 Lysate (2)

      TIMP2 Background

      Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompasses four members (TIMP1-4), and they inhibit most MMPs by forming non-covalent binary complex. TIMP2 is a 22 kDa non N-glycosylated protein expressed by a variety of cell types, and plays a unique role among TIMP family members owing to its functions to regulate cellular responses to growth factors. Findings establish an unexpected, MMP-independent mechanism for TIMP2 inhibition of endothelial cell proliferation in vitro and reveal an important component of the antiangiogenic effect of TIMP2 in vivo. TIMP-2 thus is critical to the maintenance of tissue homeostasis and is involved in the regulation of tumor microenvironment.

      TIMP2 References

      • Stetler-Stevenson, W.G. et al., 1992, Matrix. Suppl.1: 299-306.
      • Stetler-Stevenson, W.G. et al., 2005, Trends. Mol. Med. 11: 97-103.
      • Seo, D.W. et al., 2003, Cell. 114: 171-180.

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