Thyroid peroxidase Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TPO (Thyroid Peroxidase) is a protein coding gene located on human chromosome 2p25.3. TPO is also known as MSA, TPX and TDH2A. The human TPO gene encodes a 102963 Da protein containing 933 amino acids. The TPO protein is restrictedly expressed toward thyroid. Among its related pathways are Thyroxine (Thyroid Hormone) Production and Aldosterone synthesis and secretion. TPO is related to calcium ion binding and peroxidase activity. PXDN is an important paralog of TPO gene. TPO is associated with some diseases, including Thyroid Dyshormonogenesis 2A and Familial Thyroid Dyshormonogenesis.

Thyroid peroxidase Protein (1)

    Thyroid peroxidase Antibody (9)

      Thyroid peroxidase ELISA Kit & Match Antibody ELISA Pair Set (1)

      Thyroid peroxidase cDNA Clone (13)

      NM_000547.5

      Thyroid peroxidase qPCR Primer (1)

      Thyroid peroxidase Lysate (1)

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        Thyroid peroxidase Background

        Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid Peroxidase represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. It used to be taken as the formerly so-called `microsomal antigen` several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two identical subunits of approx 100 kDa molecular weight. Thyroid peroxidase is an enzyme expressed abundantly in the thyroid that liberates iodine for addition onto tyrosine residues on thyroglobulin for the production of thyroxine or triiodothyronine, thyroid hormones. Thyroid peroxidase plays a key role in the thyroid hormone biosynthesis by catalysing both the iodination of tyrosyl residues and the coupling of iodotyrosyl residues in thyroglobulin to form precursors of the thyroid hormones T4 and T3.

        Thyroid peroxidase References

        • McLachlan SM, et al. (2000) Autoimmune response to the thyroid in humans: thyroid peroxidase--the common autoantigenic denominator. Int Rev Immunol. 19(6):587-618.
        • Nagasaka A, et al. (1976) Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroid iodine peroxidase. J Clin Endocrinol Metab. 43(1): 152-8.
        • Kimura S, et al. (1987) Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs. Proc Natl Acad. 84(16):5555-9.
        • Ruf J, et al. (2006) Structural and functional aspects of thyroid peroxidase. Arch Biochem Biophys. 445 (2):269-77.

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