Thrombopoietin Proteins, Antibodies, cDNA Clones Research Reagents

THPO (Thrombopoietin) is a protein coding gene located on human chromosome 3q27.1. THPO is also known as ML, TPO, MGDF, MKCSF, MPLLG and THCYT1. The human THPO gene encodes a 37823 Da protein containing 353 amino acids. The THPO protein is biasedly expressed in liver, testis and other tissues. Among its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA. THPO is related to cytokine activity and hormone activity. THPO is associated with some diseases, including Thrombocythemia 1 and Thrombocythemia With Distal Limb Defects.

Thrombopoietin Protein (8)

    Thrombopoietin Antibody (9)

      Thrombopoietin cDNA Clone (52)


      Thrombopoietin Lysate (7)

        Thrombopoietin Background

        Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin protein is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. It has been identified that surface c-MPL, the receptor for thrombopoietin protein, binds to the ligand and mediates the action.

        Thrombopoietin References

        • Ryu T,et al.(2003) Thrombopoietin-producing hepatocellular carcinoma. Intern Med. 42(8): 730-4.
        • Higashihara M,et al. (2003) Thrombopoietin-producing tumor. Intern Med. 42(8): 632-3?

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