TGF beta 1 Proteins, Antibodies, cDNA Clones Research Reagents

TGFB1 (Transforming Growth Factor Beta 1) is a protein coding gene located on human chromosome 19q13.2. TGFB1 is also known as CED, LAP, DPD1, TGFB, IBDIMDE, TGFbeta and TGF-beta1. The human TGFB1 gene encodes a 44341 Da protein containing 390 amino acids. The TGFB1 protein is broadly expressed in spleen, bone marrow and other tissues. Among its related pathways are Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. TGFB1 is related to protein homodimerization activity and enzyme binding. TGFB3 is an important paralog of TGFB1 gene. TGFB1 is associated with some diseases, including Camurati-Engelmann Disease and Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy.

TGF beta 1 Antibody (13)

    TGF beta 1 cDNA Clone (53)


    In expression vector


    TGF beta 1 Lysate (8)

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      TGF beta 1 Background

      TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.

      TGF beta 1 References

      • Ghadami M, et al. (2000) Genetic Mapping of the Camurati-Engelmann Disease Locus to Chromosome 19q13.1-q13.3. Am J Hum. Genet. 66(1):143-7.
      • Letterio J, et al. (1998) Regulation of immune responses by TGF-beta. Annu Rev Immunol. 16:137-61.
      • Vaughn SP, et al. (2000) Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region. Genomics. 66(1):119-21.
      • Assoian R, et al. (1983) Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem. 258(11):7155-60.

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